ROSMARINIC ACID AMELIORATES MEMORY DETERIORATION AND OXIDATIVE STRESS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Vinayaka Shahavi* and Rahul Somani

ABSTRACT

Diabetes induced memory dysfunction is found to be equivalent with Alzheimer’s disease, disturbing normal physical, mental and social life of patients. Rosmarinic acid is flavonoid known to have pharmacological action against diabetes and diabetic complications. However, its effect in diabetic induced memory dysfunction and related oxidative stress has not been evaluated. Hence, present study was designed, conducted and analyzed for assessment of diabetes induced memory deterioration and oxidative changes in various parts of brain in Streptozotocin (STZ) induced diabetic rats. Diabetes was induced by streptozotocin (60 mg/kg, i.p.) in rats. After confirmation of diabetes treatment of Rosmarinic acid (12.5, 25, 50 mg/kg, p.o.) was started in separate group of animals. After 30 days diabetic rats showed significant memory deficits and also increased cholinesterase and MDA levels and depleted reduced glutathione levels in hippocampus and cerebral cortex. Moreover, chronic treatment of Rosmarinic acid had substantial influence on memory deficit in diabetic rats. Additionally, treatment of Rosmarinic acid significantly decreases blood glucose levels and MDA levels. Further, GSH levels found to be elevated in rosmarinic acid in diabetic rats. Also, cholinesterase levels are reduced which found to be elevated in diabetic rats. The result obtained from study points that treatment with Rosmarinic acid in diabetic rats ameliorates memory loss and oxidative stress.

Keywords: Rosmarinic acid, Diabetes, Memory dysfunction, Acetylcholinesterase, oxidative stress, Novel object recognition test.