EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 7.065

 ICV - 79.57

Abstract

EFFECT OF TREMA GUINEENSIS AQUEOUS AND ETHANOLIC EXTRACTS ON IRON, COPPER, ZINC AND MANGANESE DURING THE ACUTE INFLAMMATION AND OXIDATIVE STRESS IN RAT.

Kouakou Yeboue Koffi F.*, Yapo Crezoit Claire A., Yapi Houphouet Félix, Gnahoue Goueh, Djaman Allico J.

ABSTRACT

The aim of this study was to investigate in vivo effects of Trema guineensis extracts (TGE) leaves on traces element (Fe, Cu, Mn, Zn) concentrations in carrageenan induced in rats. C-reactive protein (CRP), antioxidant marker (FRAP), Copper, zinc, manganese, iron were analyzed in blood. Firstly, we evaluated the content of trace elements (Cu, Zn, Fe, Mn) in the Trema guineensis leave extracts. The ethanolic extract was richer in Cu and in Fe. Then TGE (200 mg/kg), drugs references (oligosol Cu/Zn: 0.50 mg/mL and oligosol Mn: 0.59 mg/mL) were administered to rats (N = 6) by intraperitoneal (0.5 mL). One hour after drug treatment all animals were injected with 0.2 mL of 1% suspension of carrageenan in normal saline into the subplanter region of left hind paw to induce inflammation and oxidative stress. Trace elements (Cu, Zn, Mn, Fe) were measured by flame atomic absorption spectrophotometer 5 hours later and compared to healthy controls (NaCl 0.9%). Mn, Cu, Fe and Zn concentrations varied significantly among the different groups. The ethanolic extract administering and the standard drug favored obtaining better trace elements contents. The CRP and oxidative stress by FRAP test in animals received carrageenan had confirmed its role in the installation of both pathologies in vivo. This analysis showed enough the plant extracts possess the anti-inflammatory and antioxidant activities. The analysis of iron showed that both extracts are rich in nonheminic iron.

Keywords: trema guineensis, oligosol, trace elements, carrageenan, Côte d’Ivoire.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia