EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

IN - VIVO STUDY ON INTERACTION OF KETOTIFEN FUMERATE WITH DI - CLOFENAC - NA ALONG WITH THEIR IR STUDIES

Md. Khalequeuzzaman, Md. Mominur Rahman, Mst. Rozina Parul*, Mohammed Aktar Sayeed,
Md. Nazmul Hasan

ABSTRACT

This is very much important than any other time or ever to know about the medicines we take. If we take several different medicines, suffering from various types of diseases, consult more than one doctor or have certain health conditions, we and our doctors must be aware of all the medicines we take to avoid potential problems, such as drug interactions. The study of Drug interaction between various drugs has been conducted for many years and successful results have also been established. In the continuation of the study of drug interaction we have studied the in vivo interaction between the Kitotifen Fumerate and Di-Clofenac Na along with their IR studies. In-vivo study showed decreased in the plasma concentration of free Ketotifen Fumarate when given concurrently with Di- Clofenac Na which may be due to the drug interaction. IR study confirmed that there is an interaction between Ketotifen Fumarate and Diclofenac Na with the presence of extra peaks in their combination (aqueous & chloroform extract) forms as compared to that of their pure forms. So, we can say that if both ketotifen fumerate with Di-Clofenac administer concurrently, mild complex can be formed after reaction which can ultimately reduce the pharmacological activities of both combinations of drugs.

Keywords: Kitotifen fumerate, Di-Clofenac Na, pharmacological activities & drug interactions.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)