EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

ASSOCIATION OF E-SELECTIN GENE POLYMORPHISMS IN EGYPTIANS WITH CORONARY ARTERY DISEASE

Heba Mosaad, Mohamad Motawea, Ahmed El Said and Ola El-Shimi*

ABSTRACT

Genetic polymorphisms of the E-selectin are associated with coronary artery disease. Objectives: We aimed to investigate the association between the A561C and G98T polymorphisms in E-selectin gene and coronary artery disease in Egyptian population. Subjects & methods: The study enrolled 251 individuals, classified into 2 groups: 152 coronary artery disease patients and 99 normal healthy individuals. A561C and G98T polymorphisms of E-selectin were analyzed by PCR-RFLP (Polymerase chain reaction - Restriction fragment length polymorphism) technique. Results: The frequency of C allele of the E selectin A561C polymorphism was higher in coronary artery disease patients than control group but with no statistical significant difference between the two studied groups (p=0.53). The frequency of T allele of G98T polymorphism of E-selectin was higher in coronary artery disease patients when compared to control group but with no statistical significant difference (P=0.36). Conclusion: A561C and G98T polymorphisms of E-selectin gene are not associated with the predisposition to coronary artery disease and appear to be protective in Egyptian population.

Keywords: E-selectin, polymorphism, PCR-RFLP, CAD, Egyptians.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)