MATRIX TABLETS FOR IMMEDIATE AND CONTROLLED RELEASE DRUG DELIVERY: PROS AND CONS

*Dr. Gaurav Tiwari, Dr. Ruchi Tiwari, Dr. Pranaywal, Ankita Wal and Chitranshu Gupta

ABSTRACT

Oral sustained release (SR) products provide an advantage over conventional dosage forms by optimizing biopharmaceutics, pharmacokinetics and Pharmacodynamic properties of drugs in such a way that it reduce dosing frequency to an extent that once daily dose is sufficient for penetration, polymer swelling, drug dissolution, drug diffusion and matrix erosion. Highly water soluble drugs like Diltiazem; Ranitidine has been formulated as sustained release matrix tablets. This article contains the basic information regarding design sustained release formulation and also the different types of the same. Developing oral sustained release matrix tablet with constant release rate has always been a challenge to the pharmaceutical technologist. Most of drugs, if not formulated properly, may readily release the drug at a faster rate, and are likely to produce toxic concentration of the drug on oral administration. Hydrophilic polymers have become product of choice as an important ingredient for formulating sustained release formulations.

Keywords: Extended release, Therapeutic concentration, Patient convenience and compliance.