EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

SYNTHESIS, ANTI MICROBIAL ACTIVITY AND DOCKING STUDY OF SALICYLANIDES

*A. P. Rajput and Sonali A. Patil

ABSTRACT

Discovery of new efficient antibiotics is very challenging task. Due to increasing resistance power of bacteria, fungi and viruses against many antibiotics; searching of effective antibiotic is more difficult job. Salicylanides were synthesized and evaluated for their antimicrobial activity in vitro. All the compounds are characterized by spectroscopic techniques such as FTIR, H1 NMR, C13 NMR and Mass. Molecular docking of these compounds is carried out in silico. Molecular docking of these compounds is done with β-Ketoacyl-acyl carrier protein synthase III from Escherichia coli (ecKAS III pdb id: 1HNJ) as a receptor responsible for growth of bacteria. The results show that all Salicylanides are excellent inhibitors of β-Ketoacyl-acyl carrier protein synthase III.

Keywords: Salicylanides, Molecular docking, antimicrobial activity, protein etc.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)