SYNTHESIS OF NOVEL 5, 6 – BENZ 1, 3 – OXAZEPINE 4, 7 – DIONE DERIVATIVES AND SCREENING FOR ANTIBACTERIAL, ANTIOXIDANT AND ANTIINFLAMMATORY ACTIVITIES

Anila K. Alexander*, Lincy Joseph and Mathew George

ABSTRACT

The present study involves the synthesis of series of eight number of 5,6 – Benz 1,3 – Oxazepine 4, 7 – Dione (BO.1-BO.8) derivatives by cycloaddition reaction between schiff base (semicarbazone) and phthalic anhydride with dry benzene as the solvent. Schiff base is synthesized by the condensation reaction of semicarbazide hydrochloride with various aromatic aldehydes in the presence of sodium acetate. All the theoretically synthesised compounds were screened for in vitro antibacterial (Disc diffusion method), in vitro antioxidant (H2O2 scavenging method) and in vitro and in vivo anti-inflammatory activity (protein denaturation method and carrageenan induced inflammation respectively.

Keywords: Semicarbazide Hydrochloride, Schiff bases, Cycloaddition, Phthalic anhydride, Oxazepinediones, antibacterial, antioxidant, anti-inflammatory activity.