EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia , 

 ISSN 2394-3211

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 ICV - 79.57

Abstract

CYTOPROTECTIVE EFFECTS OF AQUEOUS GINGER (ZINGIBER OFFICINALE) EXTRACT AGAINST CARBIMAZOLE-INDUCED TOXICITY IN ALBINO RATS

Saber A. Sakr*, Sobhy E. Hassab El Nabi, Yosry A. Okdah, Islam M. El-Garawani, Ahmed M. El-Shabka

ABSTRACT

Carbimazole is an antithyroid drug used to treat over active thyroid gland. On the other hand treatment with carbimazole associated with many side effects. In our research, rats treated with carbimazole for three and six weeks showed significant increase in percentage of apoptotic and necrotic cells by using dual staining of leucocytes by acridine orange and ethidium bromide. Moreover DNA fragmentation was observed after six weeks of treatment with carbimazole. Also comet assay revealed DNA damage in rats treated with carbimazole for six weeks. An increase in chromosomal aberrations were recorded with decreased cell proliferation was reflected by a decrease in mitotic index. Combined treatment with aqueous ginger (Zingiber officinale) extract and carbimazole caused a reduction in chromosomal aberrations, DNA damage and increasing cell viability by decraesing apoptotic and necrotic percentage with an increase in mitotic index. The results of this study indicated that aqueous ginger extract ameliorates the genotoxicity and cytotoxicity induced by carbimazole in albino rats and this is may be due to the potent antioxidant effects of its components.

Keywords: Zingiber officinale, Carbimazole, DNA, chromosomal aberrations, cell viability, comet assay.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia