EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

ACTIVATION OF COMPLEMENT SYSTEM ALTERNATE PATHWAY BY ANDROGRAPHIS PANICULATA, OCIMUM SANCTUM AND AZADIRACHTA INDICA

*Balaji P, Fathima N, Lakshyajit Kakati, Jaseer K.K, Uma Krithika S and Kannan K.

ABSTRACT

The effect of aqueous extracts of Andrographis paniculata (AEAP), Ocimum sanctum (AEOS) and Azadirachta indica (AEAI) on in vitro complement system alternate pathway (AP) activity was evaluated and compared with that of the known immunostimulant levamisole. The results suggest that there is a concentration dependent increase in the AP activity for levamisole, AEOS and AEAI. The activity exhibited by Andrographis paniculata was less than that of other herbs studied.

Keywords: Complement system, Alternate pathway, Haemolytic activity, Andrographis paniculata, Ocimum sanctum and Azadirachta indica.

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