EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

MICROWAVE ASSISTED SYNTHESIS AND ANTI INFLAMMATORY ACTIVITY OF SCHIFF BASE COMPLEXES DERIVED FROM META CHLORO ANILINE AND SALICYLALDEHYDE

Y. Pradeep Kumar, T. S. Mohamed Saleem and Konda Ravi Kumar*

ABSTRACT

The ligand, (2-((3-chlorophenylamino)methyl)Phenol) was synthesized by microwave method and used for the preparation of Zn (II),Co (II),Fe (II),Cu (II),Mg(II) complexes these were identified by melting point ,TLC and characterised using infrared and UV Visible spectroscopy. The infrared spectra data of this ligand and its metal complexes show that the ligand is a bidentate molecule which coordinated to the metal ions through the azomethine nitrogen and to the adjacent alkenic carbon atom. Anti inflammatory activity was conducted for all synthesized compounds by using Inhibition of albumin denaturation method (In vitro method) diclofenac sodium as reference standard.

Keywords: Ligand, metal, synthesis, Schiff base, Diclofenac.

[Full Text Article] [Download Certificate]