PALONOSETRON HCL LOADED MOUTH DISSOLVING FILM FOR EFFECTIVE TREATMENT OF CHEMOTHERAPY INDUCED NAUSEA AND VOMITING

Rakesh Patel* and Dushyant A. Shah

ABSTRACT

Aim of present work is to formulate a fast dissolving film of potent 5-HT3 specific receptor inhibitor Palonosetron HCL used in treatment of Chemotherapy induced nausea and vomiting. Fast dissolving films provide ease of administration for patient who is mentally ill, disabled and uncooperative; requires no water; have quick disintegration and dissolution of the dosage form. Formulation was prepared by the solvent casting method using Film Forming Polymer hydroxyl propyl methyl cellulose and propylene glycol, glycerin as plasticizer. Final formulation was optimized by 32 factorial design by taking concentration of polymer and plasticizer and independent variable. Film was evaluated for its stability studies, complete dissolving time, mechanical properties, tensile strength, % elongation at break, thickness of film, drug content uniformity, in vitro dissolution study, stability study, scanning electron microscopy. The studies indicate that the stable quick disintegrating and quick dissolving oral thin strip can efficiently be formulated for Palonosetron HCL.

Keywords: Fast dissolving oral films, Oral mucosa, Permeability, Solvent casting and disintegration.