REVIEW ON NOVEL APPROACHES OF GASTRORETENTIVE DRUG DELIVERY SYSTEM

N. V. Satheesh Madhav, Abhijeet Ojha and Kartik Goyal*

ABSTRACT

The aim of writing this article on gastroretentive drug delivery systems (GRDDs) is to compile the recent literature with special focus on different gastroretentive approaches. They have recently become leading methods in the field of site-specific oral administered controlled release drug delivery in the upper GIT for local or systemic effects. Afterwards, we have reviewed various gastroretentive approaches, i.e. High density (sinking), floating, bio- or mucoadhesive, expandable (Swellable), unfoldable, super porous hydrogel, magnetic system and alginate beads system. Gastroretentive dosage forms (GRDFs) are being used from a very long time to improve therapy with several important APIs. GRDDs greatly improves the pharmacotherapy of stomach by releasing the drug locally, thus result in high concentration of drug at gastric mucosa which can be sustained over a long period of time. The duration of release drug and improve bioavailability of drugs that have narrow window, by this way they prolong dosing interval and increase compliance of the patient. Finally, the factors related to GRDDs, its advantages, disadvantages, and emphasis are given over its conventional form of drug delivery in detail.

Keywords: Introduction, Anatomy and Physiology of GIT, Advantages & disadvantages of GRDDs, Suitable candidate for the GRDDs, Approaches of GRDDs.