STUDY OF FORMULATION VARIABLES ON BIOAVAILABILITY OF METFORMIN HYDROCHLORIDE

S. P. Chaudhari*, Vijaya Dhumal, S. C. Daswadkar and D. S. Shirode

ABSTRACT

The present study concentrates on the improving bioavailability of Metformin HCl which is a BCS-III drug. An attempt was made to enhance the intestinal permeability of Metformin by forming solid dispersions using β-CD, Pluronic F127 and Gelucire 50/13. The optimize solid dispersion along with dependent and independent variables like Gelucire 50/13, Pluronic F 127, which are waxy non –ionic surfactants as lubricant as well as absorption enhancer with soluble and insoluble diluents were used to formulate the formulation using design expert 9. Twenty three formulations of immediate release tablet were prepared by using steam granulation method. All the formulation was evaluated for Content uniformity, Permeability coefficient, Hardness, Friability and Disintegration Time. Of which F8 formulation was optimized as it shows high permeability than other formulations. This F8 fomulation on comparison with Marketed formulation showed more in-vivo bioavailabilty. Thus from this study it can be concluded that use of waxy non –ionic surfactants along with β-cyclodextrin played a significant role in improving the permeability and thus bioavailability of Metformin Hydrochloride.

Keywords: Metformin Hydrochloride, Permeability Coefficient, immediate release, isolated goat intestine.