ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF SPONDYLON SOFT GEL CAPSULE IN EXPERIMENTAL ANIMAL MODELS

Therasilin Louis* and Nisanth Gopinath

ABSTRACT

The present study was done to investigate the anti-inflammatory and analgesic effect of Spondylon Soft Gel Capsule (SPD), herbal combination in oil base, when compared with standard drug, Indomethacine (IND). We have determined the anti-inflammatory and analgesic activity of Spondylon Soft Gel Capsule at the doses of 3, 6, 12 and 24 mg/kg b. wt. and Indometnacine 10 mg/kg b. wt. by oral administration to healthy animals. The drug was studied for anti-inflammatory activity in carrageenan-induced hind paw edema in rats and the paw volume was measured plethysmometrically at 0 to 4 hr after treatment. The medicines were also evaluated for analgesic activity using Eddy’s hot plate method Swiss albino mice. The SPD, significantly (P<0.05) reduced carrageenan-induced paw edema in rats and analgesic activity evidenced by increase in the reaction time by Eddy’s hot plate method in albino mice. The 12mg/kg showed a good anti-inflammatory and analgesic effect comparative to the standard drugs, indomethacin. The present results indicated that 12mg/kg exhibited more significant activity than other doses 3, 6 and 24 mg/kg in the treatment of pain and inflammation.

Keywords: Anti- inflammatory, Carrageenan, Analgesic, Hot plate, Spondylon Soft Gel Capsule, Experimental animals.