ROLE OF CANCER STEM CELLS IN CERVICAL CANCER

Pooja Singh, Anand Narain Srivastava, Alka Singh, Alok Singh*, Rajveer Singh Chauhan, Siddhartha Chandel

ABSTRACT

In spite of screening and vaccination programmes, cervical cancer has become a foremost reason of cancer related deaths in women. Chemotherapy and surgery is involve in prolong survival in the patients but not give the permanent cure to patients of cervical cancer. Radical surgery is the only option for the cervical cancer at their advance stage, which also affects the childbearing capacity of the patients. Sometime it also results in the recurrence of the disease. Therefore, there is an urgent requirement to develop novel therapeutics. Hypothesis of CSCs have reported about a tumor possesses hierarchical cellular structure containing small subset of cells named as cancer stem cells inducing tumorigenesis. Many studies have reported about the CSCs tumor – initiating capacity, These CSCs play an important roles in metastasis of tumor, relapse and chemo radio-resistance. They are considered for the better outcome because they involve in the initiation of tumor propagation. The most common gynaecological malignancy is cervical carcinoma and in females it shows a high cancer mortality rate. Therefore, cervical cancer stem cells has emerged as an keen player in investigation of cervical cancer. Herein, this review, we have summarized CSCs and CCSCs as an emerging key role player in early diagnosis of cervical cancer and as a therapeutic target in this cancer.

Keywords: Cervical Cancer, Cancer Stem Cell, Cervical Cancer Stem Cell, Human Papilloma Virus.