HISTOLOGICAL AND RADIOGRAPHIC EVALUATION OF THE USE OF HYALURONIC ACID AFTER IMPACTED MANDIBULAR THIRD MOLAR SURGERY
*Ahmad Al Nashar, Mohammad Zreak, Hadi Khalil and Hasan Ghanem
This study was aimed to assess histological the radiographic outcomes of the use of hyaluronic acid HA after impacted mandibular third molar extractions. Twenty extractions of bilateral impacted mandibular third molars were performed in 10 patients (4 males, 6 females; 19 to 23 years old). After extraction of right and left mandibular third molars, the socket at one side received 1% HA gel soaked onto a pre-cut absorbable collagen sponge (test group) and the other was filled with blood clot (control group). Digital panoramic radiographs were obtained on (7 days and 4 months) postoperatively for bone density evaluation. Additionally, bone cores were harvested after 4 months from three patients and prepared for histologic evaluation.There were no statistically significant differences in bone density between the two groups at follow up periods. The biopsies harvested from the test and control sites exhibited various stages of bone maturation with mature osteocytes and formation without any inflammatory response or fibrous encapsulation. The application of 1% HA gel did not improve the histological and radiographic outcomes of osseous tissue after mandibular third molar extraction.
Keywords: Bone healing, hyaluronic acid, impacted third molar extraction, mandibular third molar socket healing.
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