PROTECTIVE ROLE OF BILIRUBIN AGAINST THE ATHEROSCLEROSIS IN METABOLIC SYNDROME

Niraj Khatri Sapkota*, Deepak Sharma, Dev Kumar Shah

ABSTRACT

Atherosclerotic cardiovascular disease characterized by a chronic inflammation of the arterial wall, which also involves deposition and peroxidation of lipids is the leading cause of morbidity and mortality both in industrialized and developing countries. Bilirubin, an endogenous antioxidant, may limit lipid peroxidation and retard the progression of atherosclerosis. However, in presence of multiple risk factors, similar concentrations of serum bilirubin may not confer the same level of protection against coronary artery disease. This review explores detailed information on the relation between the bilirubin and atherosclerosis in different disease like cardio-vascular disease (CVD), and the related diseases such as diabetes, metabolic syndrome, and obesity. All of these pathological conditions represent an important threat to human civilization, being the major killers in developed countries, with a steadily increasing prevalence. Thus, it is extremely important to search for novel markers of these diseases, along with therapeutic modalities to reverse this unfavorable situation.

Keywords: Bilirubin, peroxidation, atherosclerosis, coronary artery disease(CAD).