STUDY OF CLINICAL SPECTRUM AND MORTALITY PREDICTORS OF ARDS

Dr. Surya Prasad R.*, Dr. P. N. Venkatarathnamma, Dr. Abhishek and Dr. Prabakar K.

ABSTRACT

Acute respiratory distress syndrome (ARDS) is a clinical syndrome of severe dyspnoea of rapid onset, hypoxemia, and diffuse pulmonary infiltrates leading to respiratory failure. The acute respiratory distress syndrome (ARDS), first described in 1967, remains difficult to treat and has significant morbidity and mortality. ARDS is caused by diffuse lung injury from many underlying medical and surgical disorders. The lung injury may be direct, as occurs in toxic inhalation, or indirect, as occurs in sepsis. These conditions result in inflammatory lung injury and hypoxemia that arise from disruption of the alveolar-capillary membrane and influx of protein-rich edema fluid, producing physiologic lung dysfunction. The annual incidence of ARDS is estimated to be as high as 60 cases/100,000 population. Approximately 10% of all intensive care unit (ICU) admissions involve patients with acute respiratory failure; ~20% of these patients meet the criteria for ARDS.

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