ANTI-INFLAMMATORY AND ANTI-DIABETIC ACTIVITY OF INDIAN PROPOLIS
Shubharani Ramnath* and Sivaram Venkataramegowda
ABSTRACT
Propolis is a natural product with broad spectrum of biological properties collected by Apis mellifera bee from buds and exudates of various plant species. The chemical composition of propolis is known to alter with geographical origin leading to variation in pharmacological activities. Propolis from various geographical origins have been evaluated for antioxidant, anti-microbial, anticancer, anti-inflammatory, hepatoprotective activities, however biological properties of Indian propolis have been scarcely studied. The anti-inflammatory and anti-diabetic potential of propolis collected from South India were determined. The in-vitro anti-inflammatory potential of propolis extracts were confirmed by inhibition of albumin denaturation and membrane stabilization assay. The anti- diabetic activity was studied by inhibition of alpha-amylase enzyme and non-enzymatic glycosylation of haemoglobin method. All the studied propolis ethanol extracts possess significant anti-inflammatory and anti-diabetic activity showed dose dependent inhibition of albumin denaturation, haemolysis, alpha-amylase and non-enzymatic glycosylation of haemoglobin. The percentage of inhibition was comparable with that of the standards. The results concluded that the Indian propolis can be a promising therapeutic agent for inflammation and diabetes.
Keywords: Apis mellifera, anti-inflammatory, anti–diabetic, albumin denaturation, Alpha-amylase, propolis.
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