A STUDY ON CLINICAL EFFICACY OF N-ACETYL CYSTEINE IN ACUTE EXACERBATIONS OF COPD
M. Venkateswara Rao* and M. Venkata Sai Leela
ABSTRACT
To assess the clinical efficacy of N-acetylcysteine (NAC) in COPD patients during their acute exacerbations in chronic bronchitis (AECB). controlled study in 200 patients experiencing an acute exacerbation of COPD. Patients are divided in two groups One group is given inhalation of salbutamol, ipratpium bromide, tid, Budensonide inhalation 400 microgram, levofloxacin 250mg.Other grup contain above treatment with NAC 300mg.BID, and patients called for alternative day follow up visits for 15 days. The primary objective was to assess the proportion of patients with normalized physical, laboratory and radiological examination and pulmonary Function test to know the improvement. (Cough intensity and frequency, volume, dysapnea, fever and lung auscultation) and the conclusion is Treatment with NAC 300 mg/TID, improved biological markers and clinical outcomes in patients with COPD exacerbations. It is speculated that the effect of NAC on inflammatory markers may be due to both mucolytic and antioxidant properties.
Keywords: N-Acetyl-cysteine, COPD, exacerbations.
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