FORMULATION DEVELOPMENT AND EVALUATION OF TASTE MASKED RAPIDLY DISSOLVING FILMS OF LAMOTRIGINE

Bibaswan Mishra*, Prasanta Kumar Biswal, Prasanna Kumar Dixit and Manas Mahapatra

ABSTRACT

Rapidly dissolving dosage forms have acquired great importance in the pharmaceutical industry due to their unique properties and advantages. An effort was made to formulate a rapid dissolving films containing lamotrigine using different viscosity grade of HPMC. The prepared films can be used in the treatment of epilepsy and bipolar disorder with a view to improve the onset of action, therapeutic efficacy, patient compliance and convenience. The effect of various viscosities of HPMC alone and in blend on various properties of film was investigated. Solvent casting method was used for the preparation of film. Prepared films were typically evaluated for its physical and mechanical properties, drug content, content uniformity, disintegration time, and in vitro dissolution. The drug-excipient compatibility study was performed using FTIR. Result of the evaluation study revealed that all the formulation showed reproducible quality. Hence lamotrigine can be safely incorporated into the film and used as antiepileptic whenever quick on set of action is desired.

Keywords: Rapidly dissolving film, hydroxy propyl methylcellulose, lamotrigine, polacrilin potassium.