CLINICAL UTILITY OF CREATINE KINASE AND LACTATE DEHYDROGENASE AS SEVERITY MARKERS OF ORGANOPHOSPHOROUS COMPOUND POISONING
Dr. K. Sangeetha MD*, Dr. R. Mohandoss MD, Ajay V., Deepavarshini P. and Dr. G. Shiv Kumar MD
ABSTRACT
Organophosphorus poisoning is a major public health problem in developing countries. In India, rate of suicidal
poisoning with OPC ranges from 10.30 to 43.8%. Aim and objective: 1. To study the changes in serum levels of
LDH and CK in patients with organophosphorus compound poisoning. 2. To correlate the severity of the
poisoning with the levels of CK & LDH. Materials and Methods: In this prospective study we included 60
patients - 32 males and 28 females. The mean age of patients was 31.5 years. Based on Peradeniya
Organophosphorus Poisoning (POP) score patients were divided into (42.5%) mild, (37%) moderate, (20%) severe
cases. Results: A significantly increased serum CK, LDH levels in OPC poisoning cases than controls. The mean
levels of CK and LDH is higher in severe POP score patients (CK =312.2±53.1 IU/L, LDH=690.1±42.5 IU/L) than
moderate POP score patients (CK =291.4±75.7 IU/L, LDH=466.8±67.3 IU/L). The mean levels of CK and LDH
higher in moderate POP score patients (CK =291.4±75.7 IU/L, LDH=466.8±67.3 IU/L) than mild POP score
patients (CK =157.8±48.8 IU/L, LDH=266.7±29.5IU/L). conclusion: Early assessment the severity marker is very
important reduce the mortality. CK, LDH levels can be an efficient biomarker and can predict the prognosis OPC
poisoning.
Keywords: Organophosphorus Compound (OPC), lactate dehydrogenous (LDH), creatine kinase (CK) Peradeniya organophosphorus poisoning (POP).
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