EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

CORRELATION OF VITAMIN D3, PARATHYROID HORMONE AND SERUM CALCIUM AND LEFT VENTRICULAR HYPERTROPHY IN ESSENTIAL HYPERTENSION

Dr. Arsalan Ahmed Uqaili*, Dr. Sapna, Dr. Ashok Kumar, Dr. Omesh Kumar, Dr. Ghansham Das, Dr. Vinesh Kumar

ABSTRACT

Objective: To study and correlate vitamin D3, Parathyroid hormone (PTH) and serum calcium (Ca++) in left ventricular hypertrophy of essential hypertension Study Design: Case-control study. Subjects and Methods: A sample of 187 normal controls and 189 diagnosed essential hypertension cases were studied. Blood pressure, Echocardiography, Serum vitamin D, Ca++, PO4-, PTH, calcitonin, alkaline phosphatase (ALP), blood urea, serum creatinine, serum Na+, serum K+, urinary Ca++ and urinary PO4- were determined. Data was analyzed on SPSS 22.0 and GraphPad Prism. Results: Essential hypertension with LVH showed significantly low serum vitamin D3 (P<0.05). Serum Ca++, PO4-, PTH, Calcitonin, Na+ and urinary Ca++ and PO4- were elevated (P<0.05). Vitamin D3 (r= -0.458, p=0.0001), and urinary PO4- (r= -0.458, p=0.0001) showed negative correlation with LVH. Conclusion: LVH in essential hypertension occurs due to vitamin D deficiency caused by raised serum calcium, serum Na+ and serum Parathyroid hormone which increased myocardial contractility and protein synthesis.

Keywords: Parathyroid hormone, Vitamin D3, Calcium, left ventricular hypertrophy Essential hypertension.

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