EFFECT OF GREEN TEA ON COMPREHENSIVE METABOLIC PANEL AND HYPERLIPIDAEMIA DUE TO NICOTINE EXPOSURE IN WISTAR ALBINO RAT

Marwan M. Draid* and Khalid M. Ben-Elhaj

ABSTRACT

Background: Nicotine has a long and storied history in physiology and pharmacology. We investigated the effects of nicotine on comprehensive metabolic panel (CMP) and lipid profile within male Wistar albino rats and interaction of aqueous extract of green tea. Methods: Forty male wistar albino rats were divided into four groups of ten, controls without any treatment, green tea, nicotine, and green tea + nicotine. Over a 28 day period the control received daily subcutaneous does of saline (10 ml) and drank only water, green tea group received subcutaneous does of saline (10 ml) and drank only green tea, the nicotine group received subcutaneous does of nicotine in a saline carrier solution (10ml saline with 3mg/kg body weight of nicotine) and drank only water, and green tea + nicotine received subcutaneous does of nicotine in a saline carrier solution (10ml saline with 3mg/kg body weight of nicotine) and drank only green tea. At the end of the experiment period, blood samples were collected for biochemical analysis. Results: There were no differences between the control and green tea only groups for any parameter. The nicotine group had comprehensive metabolic panel and lipid profile concentrations significantly (P < 0.05) changes compare to control, and Green tea only groups. However using green tea with nicotine had reversed these changes. Conclusions: This study showed that injecting nicotine subcutaneously had effect on comprehensive metabolic panel and lipid profile which eliminated by aqueous extract of green tea on Wistar albino rats.

Keywords: Green tea, Nicotine, Comprehensive metabolic panel, Lipid profile.