FIBRINOGEN AS THE BIOMARKER OF SUBCLINICAL ATHEROGENESIS IN ADULT MALE SMOKERS.

*Dr. A.G. Thivyah Prabha

ABSTRACT

Smoking of cigarettes is one of the major health hazards of the world population as it is contributing to the cardiovascular diseases and to the increasing proportion of the sudden deaths. Fibrinogen is one of the independent & significant marker of cardiovascular mortality. The aim of the study is to identify the earlier marker of atherogenesis in healthy adult male smokers for the better risk prediction and screening purpose. 60 adult healthy men of age group 19-49 years were enrolled. 30 smokers & 30 non- smoker. Smokers were compared with the non-smokers by doing the blood tests which included blood glucose, lipid profile and Fibrinogen. Smokers had significantly higher levels of total serum cholesterol [245.03±72.82 vs160.07±21.39 p<0.000], LDL levels [149.17±48.87vs.98.67±14.93p<0.000] and triglyceride levels [152.43±52.40vs. 94.83±17.75p<0.000]. HDL levels were low in smokers. Fibrinogen levels were higher in smokers [644.20±231.38vs300.20±49.91p<0.000] respectively. There is a positive correlation between the duration of smoking Fibrinogen levels [r=0.917p<0.000]. This case control study shows significantly higher Fibrinogen levels in smokers in proportion to the duration & amount of cigarettes smoked pre day, as compared to the non-smokers. Thus hsCRP & Fibrinogen can be used as the bio markers of sub-clinical atherogenesis screening in healthy adult male smokers.

Keywords: Fibrinogen, Atherosclerosis, Smokers.