EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

ZINGIBER OFFICINALE EXTRACT: ANTIMICROBIAL PROPERTIES PHYTOCHEMICAL SCREENING, DRUG LIKENESS AND PHYSICOCHEMICAL STUDIES

Mohammad Arshad* and Mohd Shadab

ABSTRACT

The extract of Zingiber officinale rhizomes commonly known as ginger was obtained utilizing soxhlet extraction assembly with methanol and n-hexane as solvents. Both parts (methanol and n-hexanes) were subjected for antimicrobial screening employing disc diffusion method against S. aureus, S. epidermidis, P. mirabilis and E. Coli bacteria. Findings for antimicrobial activity portrayed that the methanol extract of ginger has more advantage over the hexane extract. The literature described that ginger extract is composed of gingerol, zingiberene, β-bisabolene, α-farnesene, shogaol, β-sesquiphellandrene and α-curcumene. The computational studies such as calculation of drug likeness and physicochemical properties were performed for all the components. The computational results showed that all the components have good bioactivity score except component-7, and out of all components, the component-2, 3, 4 and 7 were found against the Lipinski rule of five with respect to the partition coefficient. Molecular docking studies were carried out to support the experimental results which states that hydrogen bonding with the receptor is found only in case of gingerol and shogaol and both the components were found mainly in methanol extract.

Keywords: Ginger extract, antimicrobial activity, drug likeness, physicochemical and molecular docking studies.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI ) Scope Database Academia