EVALUATION OF THE HYPOGLYCEMIC AND ANTI-HYPERGLYCEMIC ACTIVITIES OF AQUEOUS AND HYDROETHANOLIC EXTRACTS OF ERYTHROCOCCA ANOMALA LEAVES IN RAT.

Miezan Bile Aka Patrice*, Kouakou Sylvain Landry, Aka Francis Beranger Angelo,
Kouakou–Siransy Giselle, Droucoula Guillaume Cyril and Yapi Houphouet Felix

ABSTRACT

Erythrococca anomala (Euphorbiaceae) is an annual medicinal plant, widely used in traditional medicine in Cote d’Ivoire and sub-Saharan Africa as an anti-inflammatory, laxative and purgative. In the present work, the aim was to evaluate the hypoglycemic and anti-hyperglycemic activity of the aqueous and hydroethanolic extracts of the leaves of this plant in the rat. The blood glucose was determined using a glucose reader Test strips). Administered orally at doses of 100 and 200 mg / kg body weight the extracts induce dose-dependent hypoglycemia in the rat. These aqueous and hydroethanolic extracts at a dose of 200 mg / kg body weight significantly reduced the hyperglycemia caused by administration by glibenclamide, the reference anti-hyperglycemic molecule (10 mg / kg body weight). Oral glucose at a dose of 5 mg / kg body weight to the rat.

Keywords: Erythrococca anomala, Euphorbiaceae, Hypoglycemic, Anti-hyperglycemic, glibenclamide.