EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 45.77

Abstract

DETECTION OF HELICOBACTER PYLORI IN MIDDLE EAR CLEFT AND ITS POSSIBLE ROLE IN CHRONIC SUPPURATIVE OTITIS MEDIA

Mohamed Abdel Moneim*, Hatem El habashy, Osama Refaat, Ahmed Abdel tawab and Osama Mostafa

ABSTRACT

Aim of the work: considering the close relationship between GERD and tubotympanic disorders, the presence of helicobacter pylori in middle ear cleft and its possible role in pathogenesis of CSOM has to be investigated. Patients and Methods: this prospective study was carried out at Al-Azhar University hospitals during the period from June 2014 to June 2016. forty patients were enrolled in this study, 25 (62.5%) were males and 15 (37.5%) were females. their age ranged from 18-58 years with a mean 36±2 years. the control group was consisted of 20 healthy persons with a mean age 22.6 years (range 19 - 29 years). written consent was taken from all patients and control subjects. CLO test was performed to all patients. 14C UBT was performed. Immunohistochemical staining to all specimens were performed using H. pylori antibody. Results: the CLO test was positive in 24 (60%) patients, and 14CUBT was positive in 26 (65%) patients. There was a significant positive correlation between CLO test results and 14C UBT results in the patients group (p˂ 0.002). The 14C UBT result of the patients and control were significantly different (p˂ 0.001). There were only 3 cases (7.5%) positive H. pylori by immunohistochemical study. Conclusion: The results of the present study does not support a role for H. pylori infection in pathogenesis of CSOM. Further studies are needed to confirm the presence of the organism in middle ear cleft and its role in pathogenesis of COM.

Keywords: GERD and tubotympanic, Immunohistochemical staining.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)