EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 45.77

Abstract

ADIPONECTIN AND RESISTIN LEVELS IN UMBILICAL SERUM OF EGYPTIAN TERM NEONATES AND RELATION TO BIRTH WEIGHT

Saad A. Mohamed*, Mohamed Zannoun, Ahmad El-Askary, Alaa Megahed and Mohamed O. Nour

ABSTRACT

Background: Optimal birth weight is an important factor for the future health of the newborns. Aberrations in fetal growth are associated with adverse health effects both in early life and in late childhood and adulthood. Fetal growth is controlled by both maternal hormones and nutrition. Adipokines, including resistin and adiponectin are known regulators of energy metabolism; although their role in the regulation of fetal growth still poorly understood. Objective: The aim of the present study was to evaluate the relationship between adiponectin and resistin with abnormalities of neonatal birth weight and to identify the correlation between these proteins and various maternal and neonatal factors. Materials and Methods: comparative controlled study included 120 full term newborns recruited from Al-Azhar University Hospital (New Damietta), during the period from January 2015 to December 2016. Included newborns were divided into 3 groups; group (I) 40 small for gestational age (SGA) newborns, group (II) 40 large for gestational age (LGA) newborns, and group (III) 40 apparently healthy appropriate for gestational age (AGA) newborns, were selected randomly. Serum umbilical cord adiponectin and resistin were measured by ELISA. Results: there was no significant difference between groups as regard to maternal age (P= 0.797), parity (P= 0.77), gestational age (P= 0.528) and BMI (P= 0.091). Umbilical cord resistin and adiponectin were significantly lower among LGA group (resistin: 16.9±1.92 ng/ml; adiponectin: 6.74±2.23 ᶙg/ml), and significantly elevated among SGA group (resistin: 23.03±3.97 ng/ml; adiponectin: 14.92±3.19 ᶙg/ml) than AGA group (resistin: 17.98±1.89 ng/ml; adiponectin: 11.04±1.91 ᶙg/ml; P < 0.001 for all). Finally, there was significant negative correlation between both resistin and adiponectin with birth weight, length and head circumference (P < 0.001 for all). Conclusion: Adiponectin and resistin might have an important role in controlling fetal growth and may be related to the occurrence of fetal macrosomia and intrauterine growth restriction.

Keywords: resistin, adiponectin, cord blood, neonates, small for gestational age, birth weight, fetal macrosomia.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)