ON TECHNOLOGIES, SAFETY AND PHARMACOLOGICAL PROPERTIES OF NEW ALNIDENT MEDICINAL PREPARATION

*Khodzhiakbarova Shakhnoza Turabekovna, Tulaganov Rustam Tursunovich and Azizov Umarhon Muhtarovich

ABSTRACT

The data on the substantiation of composition, technology and research activity of phytopreparation in the form of dental gel based on aloe and nimesulide was given. Its advantages over other compounds and forms were proved. Pharmacological properties of a new drug-dental gel Alnident developed in the Tashkent Pharmaceutical Institute have been studied. The results showed that the drug has the expressed wound-healing and strong anti-inflammatory properties. According to the classification of substances on toxicity "Alnident" preparation appeared relatively harmless. Preparation "Alnident" when applied to the skin of guinea pigs had no irritative action. In the studied doses of "Alnident" preparation - dental gel has pronounced wound-healing effect and a strong anti-inflammatory effect. Effect of "Alnident" preparation was close to "Dentashan" preparation, produced by Isshaan Healthcare Pvt. Ltd, India, while "Kamistad®" preparation produced by Stada Arzneimittel AG, Germany had a weaker effect. According to studies results of technological and biopharmaceutical factors it can be concluded that the gel has developed satisfactory dental technological and biopharmaceutical properties which allow to recommend it for use in dentistry.

Keywords: periodontal disease, dental gel, wound-healing effect, anti-inflammatory effect.