EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 45.77

Abstract

ON TECHNOLOGIES, SAFETY AND PHARMACOLOGICAL PROPERTIES OF NEW ALNIDENT MEDICINAL PREPARATION

*Khodzhiakbarova Shakhnoza Turabekovna, Tulaganov Rustam Tursunovich and Azizov Umarhon Muhtarovich

ABSTRACT

The data on the substantiation of composition, technology and research activity of phytopreparation in the form of dental gel based on aloe and nimesulide was given. Its advantages over other compounds and forms were proved. Pharmacological properties of a new drug-dental gel Alnident developed in the Tashkent Pharmaceutical Institute have been studied. The results showed that the drug has the expressed wound-healing and strong anti-inflammatory properties. According to the classification of substances on toxicity "Alnident" preparation appeared relatively harmless. Preparation "Alnident" when applied to the skin of guinea pigs had no irritative action. In the studied doses of "Alnident" preparation - dental gel has pronounced wound-healing effect and a strong anti-inflammatory effect. Effect of "Alnident" preparation was close to "Dentashan" preparation, produced by Isshaan Healthcare Pvt. Ltd, India, while "Kamistad®" preparation produced by Stada Arzneimittel AG, Germany had a weaker effect. According to studies results of technological and biopharmaceutical factors it can be concluded that the gel has developed satisfactory dental technological and biopharmaceutical properties which allow to recommend it for use in dentistry.

Keywords: periodontal disease, dental gel, wound-healing effect, anti-inflammatory effect.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)