SIMULATANEOUS SPECTROPHOTOMETRIC DETERMINATION OF ETORICOXIB AND PARACETAMOL IN TABLETS BY CHEMOMETRIC METHODS

Dr. R. Vijayageetha* and Dr. A. Shantha

ABSTRACT

Simultaneous spectrophotometric determination of Etoricoxib and Paracetamol was performed by partial least-squares (PLS) and principal component regression (PCR) methods do not require any priori graphical treatment of the overlapping spectra of two drugs in the mixture. The absorbance values in the UV-Vis spectra were measured for the 101 wavelength points (from 210-310) in the spectral region 200–400 nm considering the intervals of 1 nm. The calibration range was found to be 0.5-2.5 μg/ml for Etoricoxib, 4-20 μg/ml for Paracetamol with a correlation coefficient of 0.9999(PLS), 0.9997(PCR) for Etoricoxib and 0.9999(PLS), 0.9999(PCR) for Paracetamol. The validation of the multivariate methods was realized by analyzing the synthetic mixtures of Etoricoxib and Paracetamol. The numerical calculations were performed with the ‘Unscrambler 10.1 X’ software. The chemometrics analysis methods were satisfactorily applied to the simultaneous determination of Etoricoxib and Paracetamol in the pharmaceutical formulation.

Keywords: Paracetamol, Chemometrics, Etoricoxib, spectrophotometry, partial least square, principal component regression.