EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 45.77

Abstract

BIOMARKERS OF INFLAMMATION AND GLYCEMIA BALANCE IN TYPE 2 DIABETIC MELLITUS OUTPATIENTS IN ABIDJAN (CÔTE D’IVOIRE)

M. CISSE-CAMARA*, F.Mansour. ADEOTI, Innocent K. KOLIA, Yves E. THE, Joseph A. DJAMAN

ABSTRACT

Background: The crucial role of inflammation in the pathogenesis of type 2 diabetes mellitus remains controversial. However, most studies suggest that the production of pro-inflammatory proteins in diabetes mellitus promotes insulin resistance and the development of type 2 diabetes. The aim of the study is to assess the evolution of markers of inflammation and glycaemia in diabetic type 2 during treatment of outpatients living in Abidjan. Methods: For this purpose, 90 subjects with type 2 diabetes untreated previously (35 to 69 years, both sexes) were recruited. According to their situation, they were equally classified into insulin dependent and non-insulin dependent and treated respectively with insulin and oral antidiabetic adrugs. Glycemia, HbA1c and CRP were determined in early and 3 months after the treatment using enzymatic methods. Results: Before treatment, there was a significant mean hyperglycemia (p < 0.001) in both treatment groups, with a higher value in insulin subjects (3.95 ±0.05 g/L). The concentration of CRP was also very high (p < 0.001) in insulin dependents (15.50 ±0.42 mg/L). Three months after treatments, the mean glycemia (1.10 ±0.02 g/L) in patients treated with insulin was much reduced against those treated with oral antidiabetics (1.50 ±0.02 g/L). However for these latter, the CRP (6.31 ±0.40 mg/L) was much reduced compared to insulin dependents subjects (10.50 ±0.02 mg/L). Conclusion: These findings support the role of inflammation in the pathogenesis of type 2 diabetes and suggests the CRP consideration in blood glucose balance order to better guide therapy combining anti-inflammatory drugs.

Keywords: Type 2 diabetes, Glycemia, Inflammation, C-reactive protein.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)