INTRANASAL ROUTE FOR CNS DELIVERY: OVERVIEW AND RECENT ADVANCEMENTS
Jignesh Patel*
ABSTRACT
This review focuses on the researchers’ efforts to explore intranasal route to deliver drugs to CNS. With a brief overview of nasal anatomy, article discusses various possible mechanism through which drugs could be delivered to brain via intranasal route. Physiochemical properties of drugs affecting nasal absorption and role of formulations in brain delivery through intranasal route are discussed. Despite of the potential of nasal route to deliver the drugs to brain, enzymatic activity in nasal cavity, short residence time and higher mucociliary clearance are some of the short-comings and various approaches to overcome these short-comings are discussed. Additional focus on enhancement techniques to deliver proteins and peptides is given. In the final part of the article, some of the recent studies of intranasal delivery to brain for small molecules, protein and peptide are discussed.
Keywords: Intranasal drug delivery, CNS delivery, olfactory pathway, nasal mucosa, protein and peptide delivery, permeation enhancers.
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