EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 45.77

Abstract

CAN DEXMEDETOMIDINE BE A BETTER ALTERNATIVE TO ESMOLOL IN ATTENUATING THE IMMEDIATE STRESS RESPONSE TO DIRECT LARYNGOSCOPY AND TRACHEAL INTUBATION? – A PILOT STUDY

Dr. Shaji K R, Dr. Asish Karthik* and Dr. Sruthi Ramachandran,

ABSTRACT

Background & Objectives: Laryngoscopy and tracheal intubation trigger reflex sympathetic response often amounting to cardiovascular collapse in susceptible individuals. Perioperative physicians are in constant quest for measures to attenuate the same. Dexmedetomidine, a newer α2 agonist having titrable effects on heart rate and blood pressure, can be a better alternative to the nonselective β blocker esmolol. Methods: Fifty patients receiving general anesthesia and endotracheal intubation were randomly divided into two groups (n= 25). Group D received 0.8 mcg/kg of dexmedetomidine and group E received 2.0 mg/kg of esmolol before intubation of trachea. All patients were uniformly premedicated, induced and intubated as per standard protocol. Hemodynamic parameters were recorded at various time intervals. Statistical analysis was carried out using IBM SPSS statistics 20.0 software. A p value of 0.05 or less was set for statistical significance. Results: The decline in heart rates were highly significantat the following time intervals, ie Ti, T0B, T0A and T1 (p<0.05) and insignificant during T3(p>0.05). There was a transient rise in SBP (8% increase in group D and 6.7% increase in group E), DBP (2.9% rise in group D and 2.7% rise in group E) and MAP (5.2% increase in MAP in group D and 2.7% increase in group E) immediately following intubation. The difference between the groups was not statistically significant. Conclusion: Dexmedetomidine 0.8 mcg/kg was more effective in prevention of tachycardia compared to esmolol 2.0mg/kg.

Keywords: Direct laryngoscopy and Tracheal intubation, Stress response, Dexmedetomidine, Esmolol.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)