“A RETROSPECTIVE EVALUATION OF CLINICAL PROFILE AND EFFECTIVENESS OF OSELTAMIVIR IN H1N1 POSITIVE PATIENTS.”
Dr. Vishnugiri Goswami*, Dr. Madhu Panjwani and Dr. Krishna Lakhani
Objectives: To evaluate Clinical profile in H1N1 positive patients and effectiveness of Oseltamivir started within 48 hours and after 48 hours of onset of symptoms in H1N1 positive patients. Materials and methods: A retrospective study from Indoor cases of H1N1 positive patients (Total 141), were collected from the medical record section of Sir Takhatsinhji general hospital, Bhavnagar and scrutinized. H1N1 positive (category C; RT-PCR confirmed) patients admitted from June 2014 to April 2015 were included in the study. Data were collected in standard case record form like Demographic details, Duration of symptoms, Laboratory and X-ray findings, Treatment given, Various Complications after admission and Clinical outcome. Results: In this study total 141 patients were evaluated retrospectively among whom most of the patients were young adults like age group of 21 to 40 yrs, more residing in Urban area and gender affected was relatively equal, Total 23 patients died due to further complications and this study shows that 18 patients were with co-morbidities. Only 5 patients who died had no pre-existing history of co-morbidities. Most common symptoms were cough followed by fever, difficulties in breathing, sore throat and nasal catarrh. Other less dominant symptoms include Headache, Hemoptysis, Bodyache, Abdominal pain, Diarrheoa and Vomiting. There is significant association found between treatment (oseltamivir) given within 48 hours of symptoms onset and outcome among the swine flue patients. (p value is less than 0.05 at 1 DF and chi square value is 108.10 at 95% CI). There is significant association found between co morbidity and death among the swine flue patients. (p value is less than 0.05 at 1 DF and chi square value is 12.064 at 95% CI). Conclusion: In this study 141 patients were evaluated retrospectively among whom most of the patients, Most common symptoms were cough followed by fever, difficulties in breathing, sore throat and nasal catarrh. Death is more prevalent in those patients who have pre existing co-morbid conditions. Patients involved in this study have been treated with Oseltamivir and other supportive management, but patients who admitted within 48 hours of symptoms onset had better outcome and who were late after 48 hours of symptoms onset had developed complications more. And some patients died due to life threatening complications.
Keywords: swine flu, oseltamivir, H1N1 influenza.
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