EVALUATION OF ANTICONVULSANT ACTIVITY OF METHANOLIC EXTRACT OF GISEKIA PHARNACEOIDES LINN ON EXPERIMENTAL MICE
*Jalaiah M., Dr. Dhachinamoorthi D., Raviteja T., Purnima Devi A., Tejaswini P.
The study was performed to evaluate the Anti convulsant activity of methanolic extract of Gisekia pharnaceoides (MEGP) in Albino mice. Anti convulsant activity of MEGP was investigated by using two methods maximal electro shock induced seizures [MES] and Pentylenetetrazole [PTZ] induced seizures. Evaluation was done on both models comparing with reference standard drug phenytoin (25mg/kg) and phenobarbitone sodium [40mg/kg]. Preliminary phytochemical investigation of methanolic extract of Gisekia pharnaceoides reveal the presence of carbohydrates, flavonoids, glycosides, proteins, steroids, alkaloids and results were found that MEGP dose of 100 mg/kg and 200mg/kg decreased in the extension phase when compared with control in MES induced convulsion and in PTZ method a dose of 100mg/kg and 200 mg/kg increased onset of convulsion and decreased duration of convulsion.
Keywords: Gisekia pharnaceoides, Convulsions, MES, PTZ.
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