EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 45.77

Abstract

EVALUATION OF ANTICONVULSANT ACTIVITY OF METHANOLIC EXTRACT OF GISEKIA PHARNACEOIDES LINN ON EXPERIMENTAL MICE

*Jalaiah M., Dr. Dhachinamoorthi D., Raviteja T., Purnima Devi A., Tejaswini P.

ABSTRACT

The study was performed to evaluate the Anti convulsant activity of methanolic extract of Gisekia pharnaceoides (MEGP) in Albino mice. Anti convulsant activity of MEGP was investigated by using two methods maximal electro shock induced seizures [MES] and Pentylenetetrazole [PTZ] induced seizures. Evaluation was done on both models comparing with reference standard drug phenytoin (25mg/kg) and phenobarbitone sodium [40mg/kg]. Preliminary phytochemical investigation of methanolic extract of Gisekia pharnaceoides reveal the presence of carbohydrates, flavonoids, glycosides, proteins, steroids, alkaloids and results were found that MEGP dose of 100 mg/kg and 200mg/kg decreased in the extension phase when compared with control in MES induced convulsion and in PTZ method a dose of 100mg/kg and 200 mg/kg increased onset of convulsion and decreased duration of convulsion.

Keywords: Gisekia pharnaceoides, Convulsions, MES, PTZ.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)