ACANTHOSIS NIGRICANS, ?-CELL FUNCTION AND INSULIN RESISTANCE IN TYPE 2 DIABETIC SUBJECTS
*Dr. Omesh Kumar, Dr. Burhan Memon, Dr. Bilal Razaque Memon, Dr. Raheela Hassan, Dr. Amerta, Dr. Sanya Badar
ABSTRACT
Objective: To study the acanthosis nigricans (AN) as marker of β-cell function and insulin resistance in type 2 diabetic subjects. Study design: Observational study. Place and duration: Department of Medicine, Liaquat University of Medical and Health Sciences Jamshoro/Hyderabad from March 2016 to September 2016. Subjects and Methods: A sample of 70 type 2 DM subjects was divided into 2 groups with and without AN. Random and fasting blood glucose, fasting insulin, HbA1c, blood lipids, serum creatinine and bilirubin were detected and HOMA-IR model was calculated on computer. Data was analyzed on SPSS 22.0 (USA) software at 95% confidence interval (P ≤ 0.05). Results: Type 2 diabetics with acanthosis nigricans showed association with insulin resistance. The %β-cell function and %S (insulin sensivity) showed negative correlation and HOMA-IR (insulin resistance) showed positive correlation with acanthosis nigricans. Systolic and diastolic BP, random and fasting blood glucose, fasting insulin, HbA1c, triglycerides, LDLc, HDLc, and total cholesterol showed significant derangement in type 2 diabetics with Acanthosis nigricans. Conclusion: The present study proposes the acanthosis nigricans is a marker of insulin resistance which may be utilized in clinical practice and the HOMA-IR can serve as a marker of insulin resistance.
Keywords: Acanthosis nigricans, Insulin resistance, ?-cell function, Diabetes mellitus.
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