EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

ESTIMATION OF PARACETAMOL, ASPIRIN, IBUPROFEN, CODEINE AND CAFFEINE IN SOME FORMULATED COMMERCIAL DOSAGE USING UV – SPECTROSCOPIC METHOD.

Ahmed Mahdi Saeed* and Noor Qasim Ahmed

ABSTRACT

The estimation of paracetamol (PCM), aspirin (ASP), ibuprofen (IB), codeine (COD) and caffeine (CAF) drugs percentage in standard and some formulated commercial dosage using UV-Spectroscopic method was investigated in this work. The absorption maxima of drugs were found to be at (244.8 nm, 238 nm, 220.6 nm, 278 nm and 272.6 nm) for PCM, ASP, IB, COD and CAF respectively in deionized water: acetonitrile (90:10 v/v) as solvent. These wavelengths were selected for the analysis of drugs as standard and formulated samples. The purposed method obeyed Beer-Lambert's Law in the concentration range of (0.4-40 μg/mL) for PCM, (0.5-100 μg/mL) for ASP, (0.4-40 μg/mL) for IB, (1-100 μg/mL) for COD and (0.2-20 μg/mL) for CAF with R2 values of (0.9994, 0.9989,0.9992, 0.9995 and 0.9979) for PCM, ASP, IB, COD and CAF respectively. Recovery means were found to be (100.05, 102.20, 102.88, 100.17, and 99.95) for PCM, ASP, IB, COD and CAF. The method was applied for the estimation of the active gradient of the drugs in different samples of formulated dosage. The accuracy of method was validated by mean percentage recovery which was found to be in the acceptable range.

Keywords: Estimation, UV- Spectroscopic, Formulated, Recovery.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)