EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 45.77

Abstract

EVALUATION OF ANTIOXIDANT AND HEPATOPROTECTIVE ACTIVITIES OF MORINGA (MORINGA OLEIFERA) LEAVES IN DIABETIC RABBITS

Adel R. Shaat, Kadry M. Sadek*, Ali H. El-Far, Sherif M. Nasr and Yasser El-Sayed

ABSTRACT

Background: Because of the potential antioxidant, anti-inflammatory, and immune-modulating properties of Moringa (Moringa oleifera), there is an increased interest in its potential role in the prevention and control of diabetes mellitus (DM). Objective: This study evaluated the potential antidiabetic efficacy of Moringa oleifera leaves (MOL) powder against streptozotocin (STZ)-high-fat diet (HFD) induced diabetic rabbits. Material and methods: Forty rabbits were divided into four groups of ten animals each. Control group, received no any treatment; diabetic group, injected STZ (35 mg/ kg BW, i.p) and fed on HFD; MOL50 group, received MOL, 5% of the diet and MOL100, received MOL, 10% of diet. Results: The STZ - HFD induced diabetic rabbits exhibited a significant increase in blood glucose, lipid peroxidation, liver enzymes and renal functions as well as decrease in insulin, antioxidant enzymatic activities and catalase mRNA expression compared with the control group. However, concurrent administration of MOL normalized the levels of all these parameters compared with the diabetic group. Discussion and conclusion: MOL ameliorated the adverse biochemical effect of DM, likely by increasing insulin secretion and sensitivity, improving the antioxidant status and decreasing the lipid peroxidation and insulin resistance.

Keywords: Antioxidant status, Moringa oleifera, Streptozotocin, Hepatoprotection.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)