EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

EFFECT OF TARTRAZINE ORALLY ADMINISTERED ON THYROID HORMONES AND THYROID STIMULATING HORMONE OF ALBINO RATS

*Elekima Ibioku, Nwachuku Edna Ogechi and Ben-Chioma Adline Erinma

ABSTRACT

The effect of tartrazine orally administered on thyroid hormones and thyroid stimulating hormone on albino rats were evaluated. Thirty rats (30) weighing approximately 0.14kg were used for the experiment. The rats were divided into five groups namely C1, C2, C3, C4 and C5. Each group consist of six (6) rats. When the data obtained were analysed statistically, Group 1 (control) had 0.1900 ± 0.0872; 2.618 ± 0.6002 and 0.8300 ± 0.3712 for TSH, T4 and T3 respectively. Group 2 had 0.2000 ± 0.2800; 2.758 ± 0.3704 and 1.243 ± 0.3806 for TSH, t3 and t3 while group 3 had 0.1467 ± 0.0242; 2.893 ± 0.6330 and 0.9150 ± 0.2367 for TSH, T4 and T3 respectively. In addition, group 4 had 0.1100 ± 0.0179; 2.878 ± 0.1217 and 1.448 ± 0.2498 for TSH, T4 and T3 respectively and finally, group 5 0.0933 ± 0.0301; 3.447 ± 0.6836 and 1.230 ± 0.4808 respectively. The comparison between group 1 (control) and group 2, group 1 and group 3 and group 1 and group 4 were compared, TSH, T4 and T3 were not significant except in group 1 and group 4 were T3 was significant at p<0.05. When group 1 and group 5 were compared, TSH and T4 were significant at p<0.05 while T3 was not significant at p<0.05. This study revealed that oral intake of synthetic dye such as tartrazine especially in high doses led to increase in thyroid hormones and reduction in TSH of albino rats.

Keywords: Tartrazine, Triiodothyronine (T3), thyroxine (T4), TSH.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)