EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 45.77

Abstract

HISTOLOGICAL CHANGES IN THE CEREBELLUM OF ADULT WISTAR RATS FOLLOWING ADMINISTRATION OF ETHANOLIC EXTRACTS OF LEMONGRASS AND MANGO BARK

Mokutima A. Eluwa, Etim E. Asuquo, Olaitan R. Asuquo*, Theresa B. Ekanem, Amabe O. Akpantah, Mfoniso Udonkang and Sophia O. Amah

ABSTRACT

This research work focused primarily on the histological features of Wistar rats cerebellum following the administration of the ethanolic extracts of lemongrass, mango bark and its combined extracts. Twenty adult Wistar rats weighing 180-220g were divided into four groups labeled A, B, C and D. Group A rats served as the control and were fed with rat chow throughout the duration of the experiment. Group B animals received 2000mg/kg of the ethanolic extract of lemongrass, group C animals received 2000mg/kg of ethanolic extract of mango bark while group D animals received combined ethanolic extracts of 1000mg/kg of lemongrass and 1000mg/kg of mango bark orally for two weeks. The animals were sacrificed 24 hours after the last administration using chloroform inhalation method. The cerebellum were excised and preserved using 10% formal saline. Routine paraffin wax tissue processing was carried out and sections stained using Hematoxylin and Eosin. Histological observations revealed in the control rats normal cerebellar cytoachitecture. Cerebellum of the treated groups showed slight degeneration and loss of purkinje cells, which was more in group D when compare with groups B, C and the control group. Result showed that the extract may individually and in combined form cause alterations in the cerebellum cytoarchitecture.

Keywords: Cerebellum, Histology, Ethanolic extract, Lemongrass, Mangobark, Wistar rats.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)