EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

ODONTOCLAST: A BRIEF OVERVIEW

Dr. Purva Prakash Patil* and Dr. Priya Anil Bhagde

ABSTRACT

Odontoclasts are responsible for resorption of dental hard tissues in various physiological and pathological oral conditions. These cells are usually studied and compared with osteoclasts because of some overlapping morphological and biochemical characteristics. However, there are still some differences. Some studies had shown that, similar to osteoclastogenesis RANK, RANKL and OPG are involved in odontoclastogenesis. Also, similar pathways [alphav)beta3) integrin pathway and c-Fms pathway] seem to operate during activation of both odontoclasts and osteoclasts. According to certain contradictory studies response of odontoclasts to parathyroid hormone extract and certain drugs was found to be different from that of osteoclasts. Thus, it can be proposed that there might be additional pathways involved in formation and activation of odontoclasts. Physiological root resorption is seen only during shedding of deciduous teeth. Whereas pathologic root resorption can be due to various causes like trauma as in orthodontic treatment, hormonal imbalance, various cysts and tumors affecting jaw bones and periodontal disease. Pathways for formation and activation of odontoclasts can vary slightly among these pathologies. Thus, further studies are necessary to have a clear molecular insight in formation and activation of odontoclasts which might help to develop modalities to prevent pathological dental resorption.

Keywords: Odontoclast, Alpha?v)beta?3) integrin pathway c-Fms pathway, root resorption.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)