EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

QUANTITATIVE ESTIMATION AND VALIDATION OF ATENOLOL AND AMLODIPINE BESYLATE BY ABSORBANCE RATIO (Q) METHOD.

Rahul K. Godge*, Ganesh S. Shinde and Nachiket S. Dighe

ABSTRACT

The simple, rapid, accurate, precise, cost effective, and reproducible UV spectroscopic method have been developed for the simultaneous estimation of atenolol and amlodipine besylate in bulk and combined tablet dosage form. Atenolol and amlodipine have absorption maxima at 224 and 238.2 nm respectively. Beer’s law obeyed in concentration range of 2‐24 μg/ml and 2‐34 μg/ml for Atenolol (ATN) and Amlodipin (AMN) respectively. The method of Q analysis is based on measurement of absorptivity at 224 nm and at isoabsorptive point 232.2 nm. The recovery studies from tablet are indicative of accuracy of method and are found in between 99.05‐101.16% at three different levels of standard additions. Precision studies showed satisfactory results. A novel approach to use 0.1N HCL as solvent is proved to be beneficial with respect to cost, stability and avoidance of organic solvent.

Keywords: Atenolol, Amlodipine Besylate, 0.1 N HCL, Q Method.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)