COMPARATIVE ANALYSIS OF COMPLEXATION OF LABETALOL & CHLORTHALIDONE WITH Cu (ll) ION - A SPECTROPHOTOMETRIC STUDY
Dr. Namita Bhardwaj* and Jaishri Kaushik
UV- Visible spectrophotometric is a selective method for determination of the complexation of drugs with Cu(ll) Metal ion. The proposed method is based on the reaction of selected drugs with Cu(ll) ion. The formed complex were absorbed maximally at 350nm & 250 nm. The different experimental parameter affecting the development of the colour were carefully studied and optimized Here the selected drug labetalol is β-blocker having amino group so the chealation with cu ion is easy and stable and clorothalidone is diuretics thiazide (sulphur containing group) so the chealation is maximum with cu metal ion.
Keywords: complexation, spectrophotometric, absorbance, labetalol, chlorthalidone, stability constant.
[Full Text Article]