EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 79.57

Abstract

ISOLATION AND CHARACTERIZATION OF ANTI-HYPERGLYCEMIC COMPOUND FROM FRACTIONATION OF ETHANOLIC EXTRACT OF KALANCHOE PINNATA LEAF.

Dr. Pradeep Goyal*, Dr. Jitender Singh, Nishant Thakur and Dr. Manish Goswami

ABSTRACT

The present study was aimed to evaluate the effect of active compounds from Kalachoe pinnata leaves on blood glucose level in normal and diabetic rats. Diabetes was induced by Streptozotocin (STZ) in male wistar rats. An isolated fraction of EEKP (600 mg/kg b. wt.) and Glibenclamide (10 mg/kg b.wt.) was administered orally. An isolated fractions showing for higher antihyperglycemic activity was subjected to column chromatography that led to isolation of a pure compound, which was given trivial name KP-1. The fraction H from EEKP was found to lower the blood glucose level significantly (P<0.05) in diabetic rats. To ensure the compounds responsible for anti-hyperglycemic activities associated with H respectively. Further column chromatographic analysis was carried out using various solvent systems and which was given trivial name KP-1. KP-1 was phenolic compound nature (Flavonoids) confirmed by spectral analysis.

Keywords: K.pinnata, Antihypergycemic, Flavanoid.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)