EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 45.77

Abstract

TO ASSESS THE WOUND HEALING PROPERTY OF TOPIRAMATE – EXCISION MODEL IN IMMUNOSUPRESSED ALBINO RATS

Dr. Dwajani S.*, Abhijit B.R. and Dr. Sahajananda

ABSTRACT

Aim: To evaluate the wound healing activity of Topiramate [TPM] in excision model and to study its effects on Dexamethasone suppressed wound healing. Methods: For assessment of wound healing activity excision model was used. Group I received distilled water, orally, Group II, Group III and Group IV received increasing doses of TPM, p.o, Group V received Dexamethasone intramuscularly (i.m) and Group VI, Group VII, Group VIII received Dexamethasone i.m and TPM, p.o. Parameters observed were epithelization and wound contraction of excision model. Results: The TPM exhibited significant wound healing activity as compared to control in excision wound model. No statistical significant results were shown in any of the groups treated with dexamethasone. Discussion: Since TPM to certain extent enhances wound contraction it would have either enhanced contractile property of myofibroblasts or increased the number of myofibroblasts recruited into the wound area. Hence, it is concluded that TPM may be capable of promoting wound healing activity.

Keywords: Wound Healing, TPM, Dexamethasone, Excision.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)