EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

RESEARCH ARTICLE ON: FORMULATION & EVALUATION OF SUSTAINED RELEASE MICROSPHERE OF CEFIXIME TRIHYDRATE BY IONIC GELATION TECHNIQUE

Saurabh, Nisha Devi, Shweta Aggrwal* and Dr. R. B. Sharma

ABSTRACT

Microspheres are small spherical particles, with diameters range 1 μm to 1000 μm. They are spherical free flowing particles with size less than 200 μm and consisting of proteins or synthetic polymers which are biodegradable in nature microsphere is basically a mixture of drug, dispersed in a polymer form with release occurs by 1st order process. Microspheres are two types; microcapsules and micromatrices in case Microcapsules are those in which entrapped substance is distinctly surrounded by distinct capsule wall. And micromatrices in which entrapped substance is dispersed throughout the matrix. They are made from polymeric waxy or other protective materials such as natural, semi synthetic and synthetic polymers. Most of sustained release dosage form follows the mechanism of diffusion, dissolution or combination of both, to produce slow release of drug at predetermined rate. Hypothetically, a sustained release dosage form should release the drug by a zero-order mechanism which maintains drug plasma level time similar to intravenous infusion. . Cefixime has high affinity for penicillin-binding proteins (PBP) 3, la and Ib. Its affinity for PBPIb explains the rapid lytic action of cefixime relative to that of the other orally active cephalosporins. The spectrum was scanned over a wave number range of 4000 cm-1 to 1 cm-1. thermogram figure 2.3 of cefixime trihydrate shows broad endothermic pea at 21 , which is its melting point as cefixime melt with decomposition over the range 21 - 225 . λmax value of cefixime trihydrate was found to be 288 nm. Finally result correlation coefficient (R2) was used as an indication of the best fit, for each of the model considered. Considering the correlation coefficient (R2) values as obtained from the different kinetic equations, the drug release from the optimized formulation F8 mainly follows zero order as best linearity was found in zero order (R2 = 0.9944) as indicated by their highest correlation coefficient value as compared with other models.

Keywords: Microsphere, Sustained release, Ionic gelation technique, Cefixime Trihydrate Drug.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)