EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (Under Process) , 

 ISSN 2394-3211

Impact Factor: 4.897

 ICV - 79.57

Abstract

EVALUATION OF MELANOGENIC AND ANTI-VITILIGO ACTIVITIES OF HOMEOPATHIC PREPARATIONS ON MURINE B16F10 MELANOMA CELLS

Joshi Samidha, Munshi Renuka, Talele Gitanjali and Shah Rajesh*

ABSTRACT

Background: Vitiligo is a multi-factorial disorder where the skin loses pigments. Homeopathic medicines are known to be effective for vitiligo. The melanogenic activity of homeopathy has not been evaluated in lab models. Materials and Methods: Cell viability assay was performed to observe the cytotoxic effect of homeopathy preparations on melanoma cells. The effect of homeopathy preparations on the production of melanin in melanocytes was determined using B16F10 melanoma cells. The activity was checked at the end of 48 and 96 hours using 30c potency and 1:1 dilutions of homeopathy preparations. Result: Cell viability assay results showed no cytotoxic effect on the cells. Hydroquinone, Arsenicum sulphuratum flavum (ASF) and Phosphorous (30C) potency showed increase in melanin content as compared to cell and vehicle controls. However, statistically significant increase was seen with Hydroquinone and ASF. The diluted form (1:1) of all the three homeopathy preparations exhibited slight increase in the melanin content as compared to both the controls but was less as compared to cell control. At the end of 96 hours, ASF and Phosphorus exhibited a slight increase in melanin content as compared to potentized control. There was no inhibition of Tyrosinase activity seen during the assay with the homeopathy preparations. Discussion and Conclusion: The experiment has thrown important finding supporting the very fundamental homeopathy principle, by stimulating melanogenesis in the small (potentized) dose of the substance which in the crude form is known to be induce vitiligo.

Keywords: Vitiligo, Hydroquinone, Arsenicum sulphuratum flavum, Phosphorus, homeopathy.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (Under Process)