EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

SYNTHESIS, CHARACTERIZATION AND CYTOTOXIC EVALUATION OF 5-[4-(1HIMIDAZOL- 1-YL)PHENYL]-3-(2,4,6-TRIMETHYLPHENYL)-4,5-DIHYDRO-1,2- OXAZOLE DERIVATIVES BY USING MTT ASSAY METHOD

Gondu Eswara Rao*, S. A. Rahaman and A. Prameela Rani

ABSTRACT

The isoxazoline derivatives were synthesized from chalcone as intermediate compound. the chalcones were reacted with hydroxyl amine in presence of glacial acetic acid and sodium acetate to form cyclic compound isoxazoline derivatives and the structures were confirmed by spectral evidence. The compounds were tested for cytotoxic evolution by MTT assay method. . In these test compounds, The compound IS-02, (45-[4-(1H-imidazol-1-yl)phenyl]-3-(3,4,5-trimethyl phenyl)- 4,5-dihydro-1,2-oxazole 15Â±2 Î¼g/ml, 18Â±1 Î¼g/ml,12Â±1 Î¼g/ml against the Breast cancer (MDA MB, Colon cancer (HT-29), Prostate cancer(DU-145)

Keywords: Isoxazoline derivatives, urea, cytotoxicity, MTT assay method.

[Full Text Article] [Download Certificate]