QSAR STUDY AND EVALUATION OF IN VITRO ANTI-INFLAMMATORY ACTIVITY FOR 1H-BENZOTRIAZOL-1-YL{2-HYDROXY-5- [(E) PHENYLDIAZENYL]PHENYL}METHANONE DERIVATIVES

C. M. Jamkhandi*, P. S. Kumbhar, J. I. Disouza, S. M. Patil

ABSTRACT

The purpose of present work is to study in vitro anti-inflammatory activity of 1H-benzotriazol-1-yl{2-hydroxy-5- [(E) phenyldiazenyl]phenyl}methanone derivatives (BZT). Anti-inflammatory activity was measured for each derivative to study the QSAR of the derivatives with Hansch and Free Wilson model. Egg albumin protein precipitation method was used to study in vitro anti-inflammatory activity. Diclofenac was used as standard and absorbance of samples, standard and control was measured spectrophotometrically at 660 nm. Five derivatives were screened for anti-inflammatory activity, out of which the compounds S2, S3 showed medium anti-inflammatory activity, S1, S5 showed better anti-inflammatory activity in comparison with standard and S4 showed more activity than standard. Contribution of different substituent on benzotriazole was reported. All the samples showed anti-inflammatory activity in comparison with Diclofenac.

Keywords: Benzotriazole, QSAR, anti-inflammatory activities, physico-chemical parameters.